Dominique D. Bailey, MD, MSEd h1 >
Title: Instructor in Pediatrics, Department of Pediatrics, Columbia University Irving Medical Center
Affiliation: Columbia University
Year entered into CEGIR training program: 2018
Mentor/s: Dr. Marc Rothenberg, MD, PhD
Dr. Bailey is a physician-scientist in basic-translational science whose long-term clinical and research goal is to improve the lives of children with eosinophilic esophagitis (EoE). As a practicing pediatric gastroenterologist with research training in developmental biology and cellular & molecular biology, her research goal is to investigate the cellular and molecular mechanisms of EoE. Dr. Bailey’s research focuses on advancing our current understanding of pathophysiology of pediatric EoE to further elucidate treatment targets and novel biomarkers specific to pediatric EoE.
Summary of current CEGIR projects
Dr. Bailey’s project with CEGIR involves identifying the function of a subset of genes associated with IL-13, which have been found to be upregulated in patients with EoE. Clinical trials have demonstrated that blocking the IL-4/IL-13 pathway has been helpful in the treatment of EoE. Her project is to further understand how these genes are involved in the pathogenesis of EoE and to determine whether these genes could serve as novel treatment targets for EoE.
Publications as affiliated with CEGIR
- Nakagawa H, Kasagi Y, Karakasheva TA, Hara T, Aaron B, Shimonosono M, Kijima T, Giroux V, Bailey D, Wilkins B, Abrams JA, Falk GW, Aceves SS, Spergel JM, Hamilton KE, Whelan KA, Muir AB. Modeling Epithelial Homeostasis and Reactive Epithelial Changes in Human and Murine Three-Dimensional Esophageal Organoids. Curr Protoc Stem Cell Biol. 2020 Mar;52(1):e106. PubMed PMID: 32105412
- Bailey DD, Zhang Y, van Soldt BJ, Jiang M, Suresh S, Nakagawa H, Rustgi AK, Aceves SS, Cardoso WV, Que J. Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus. Development. 2019 Dec 4;146(23). PubMed PMID: 31748205; PubMed Central PMCID: PMC6918786.
Q & A with Dr. Bailey
How has CEGIR participation made a difference in your career, or how do you anticipate it will?
“CEGIR has given me the opportunity to form a collaborative network with junior investigators in basic, translational and clinical research related to eosinophilic gastrointestinal diseases as well as form mentoring relationships with leading experts in the field.”
How do you feel the patient community benefits from the CEGIR training program?
“The CEGIR training program allows physicians from several areas of expertise to work together with the objective of advancing our understanding of eosinophilic gastrointestinal diseases resulting in improved care for our patients.”