Diseases Studied

Eosinophilic gastrointestinal disorders are a group of chronic immune system disorders in which a type of white blood cell (eosinophils) build up in the gastrointestinal tract, causing inflammation or injury. These disorders include eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis, eosinophilic enteritis, and eosinophilic colitis.

Dr. Marc Rothenberg, MD, PhD, accompanies a CEGIR patient on a tour of the research laboratory located at Cincinnati Children's Hospital

Eosinophilic Colitis

A disorder in which eosinophils (white blood cells of the immune system) build up in the colon (the longest part of the digestive tract), causing tissue damage. Symptoms, including diarrhea, abdominal pain, malnourishment, weight loss, and fatigue, are painful and lifelong, making it difficult or impossible for affected individuals to eat many or all foods

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A disorder in which eosinophils (white blood cells of the immune system) build up in the esophagus (the tube that carries food from the mouth to the stomach). This immune response occurs as a reaction to foods, allergens, or acid reflux, causing tissue damage. Symptoms can be painful and lifelong, making eating hard or impossible. These include difficulty swallowing, food getting stuck in the throat, vomiting, reflux, malnourishment, and poor appetite.

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A disorder in which eosinophils (white blood cells of the immune system) build up specifically in the stomach. This immune response occurs due to a food or allergen hypersensitivity, causing tissue damage. Symptoms are painful and lifelong, making eating hard or impossible. These include heartburn (acid reflux), dyspepsia (abdominal pain), nausea, vomiting, weight loss, and bloating, possibly due to ascites (fluid accumulation in the abdomen).

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A rare disorder in which eosinophils (white blood cells of the immune system) build up in the stomach and/or intestines. This immune response occurs due to a food or allergen hypersensitivity, causing tissue damage. Symptoms can be painful and lifelong, making eating hard or impossible. These include heartburn (acid reflux), dyspepsia (abdominal pain), nausea, vomiting, weight loss, and bloating, possibly due to ascites (fluid accumulation in the abdomen

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